ブックタイトルカテーテル関連尿路感染の予防のためのCDCガイドライン 2009｜株式会社メディコン

概要

カテーテル関連尿路感染の予防のためのCDCガイドライン 2009｜株式会社メディコン

V. BackgroundUrinary tract infections are the most common type of healthcare-associated infection, accountingfor more than 30% of infections reported by acute care hospitals. 19 Virtually all healthcareassociatedUTIs are caused by instrumentation of the urinary tract. Catheter-associated urinarytract infection (CAUTI) has been associated with increased morbidity, mortality, hospital cost, andlength of stay. 6-9 In addition, bacteriuria commonly leads to unnecessary antimicrobial use, andurinary drainage systems are often reservoirs for multidrug-resistant bacteria and a source oftransmission to other patients. 10,11DefinitionsAn indwelling urinary catheter is a drainage tube that is inserted into the urinary bladder throughthe urethra, is left in place, and is connected to a closed collection system. Alternative methodsof urinary drainage may be employed in some patients. Intermittent (“in-and-out”) catheterizationinvolves brief insertion of a catheter into the bladder through the urethra to drain urine at intervals.An external catheter is a urine containment device that fits over or adheres to the genitalia and isattached to a urinary drainage bag. The most commonly used external catheter is a soft flexiblesheath that fits over the penis (“condom” catheter). A suprapubic catheter is surgically insertedinto the bladder through an incision above the pubis.Although UTIs associated with alternative urinary drainage systems are considered deviceassociated,CAUTI rates reported to the National Healthcare Safety Network (NHSN) only refer tothose associated with indwelling urinary catheters. NHSN has recently revised the UTIsurveillance definition criteria. Among the changes are removal of the asymptomatic bacteriuria(ASB) criterion and refinement of the criteria for defining symptomatic UTI (SUTI). The timeperiod for follow-up surveillance after catheter removal also has been shortened from 7 days to48 hours to align with other device-associated infections. The new UTI criteria, which took effectin January 2009, can be found in the NHSN Patient Safety Manual(http://www.cdc.gov/nhsn/library.html).The limitations and heterogeneity of definitions of CAUTI used in various studies present majorchallenges in appraising the quality of evidence in the CAUTI literature. Study investigators haveused numerous different definitions for CAUTI outcomes, ranging from simple bacteriuria at arange of concentrations to, less commonly, symptomatic infection defined by combinations ofbacteriuria and various signs and symptoms. Futhermore, most studies that used CDC/NHSNdefinitions for CAUTI did not distinguish between SUTI and ASB in their analyses. 30Theheterogeneity of definitions used for CAUTI may reduce the quality of evidence for a givenintervention and often precludes meta-analyses.The clinical significance of ASB in catheterized patients is undefined. Approximately 75% to 90%of patients with ASB do not develop a systemic inflammatory response or other signs orsymptoms to suggest infection. 6,31 Monitoring and treatment of ASB is also not an effectiveprevention measure for SUTI, as most cases of SUTI are not preceded by bacteriuria for morethan a day. 25 Treatment of ASB has not been shown to be clinically beneficial and is associatedwith the selection of antimicrobial-resistant organisms.< 原文 > V. Background71